Location

Haartmaninkatu 4

Date

13 Apr 2018

Neuroscience Center seminar series

Neuroscience Seminar 

 

Speaker: Zsolt Lenkai (CNRS/ESPCI, Paris, France)

 

Cannabinoid-induced actomyosin contraction shapes neuronal structure and connectivity at multiple spatiotemporal scales

 

We have recently shown rapid cannabinoid-induced remodeling of the neuronal actomyosin cytoskeleton with potentially important roles in developmental brain wiring. Our recent results indicate a role for cannabinoid-induced actomyosin contraction also in synaptic plasticity. Completing our in vitro and ex vivo tools, we participate in the interdisciplinary development of a new in vivo imaging modality, functional fast brain ultrasound (fUS), to investigate the role of cannabinoid-induced actomyosin contraction in the structure and connectivity of the living rodent brain. fUS offers fMRI-like functional imaging, both in anaesthetised and awake animals, with spatio-temporal resolution gains of several orders of magnitude as compared to fMRI.

 

Recent relevant publications:

Tiran et al. Ultrasound Med Biol. 2017

Renard et al. Eur Neuropsychopharmacol. 2016

Chatelin et al. Journal of Cerebral Blood Flow and Metabolism, 2016

Errico et al. Nature, 2015

Roland et al. eLife, 2014

Osmanski et al. Nature Communications, 2014

 

Host: Leonard Khiroug, please call him at 045 635 2270 to arrange a personal meeting with Prof. Lenkai